ARCHIVES
VOL. 6, ISSUE 5 (2021)
Estimation of total flavonoids and molecular docking of important flavonoids of Sacostigma kleinii family-Icacinaceae with MAO-A
Authors
Elizabeth Abraham P, Jyoti Harindran
Abstract
Sarcostigma kleinii Wight & Arn. (Erumathali,Odal,Vattodal,Velloda in Malayalam) is one of the potential medicinal plants, widely used as a source of drug in the treatment of several diseases including psychiatric illness.Depression, or major depressive disorder, is a mental health condition marked by a feeling of sadness, isolation and despair that affects how a person thinks, feels and functions. Objective of this study was to investigate total flavonoids in the ethyl alcohol extract of plant leaves (EAESk) by spectrophotometric method and molecular docking with MAO- A using software Autodock 4.2 using graphical interface pyrex. Total Flavanoid content of EAESk in terms of quercetin units.was found to be 28.06% by spectrophotometric method. Luteolin (a flavone) docked with docking score -8.5 which is having 5, 7, 3′ and 4′ substituted hydroxyls and a double bond presence at carbons 2 and 3, which are responsible for their multiple pharmacological effects. Quercetin (a flavonol) docked with docking score -8.3 that has an OH group attached at positions 3, 5, 7, 3′, and 4′. From these results we can conclude anti-depressant potential of Ethyl alcoholic extract of leaves of Sarcostigma kleinii in depression like symptoms due to presence of flavonoids which binds with MAO-A.
Download
Pages:551-555
How to cite this article:
Elizabeth Abraham P, Jyoti Harindran "Estimation of total flavonoids and molecular docking of important flavonoids of <em>Sacostigma kleinii</em> family-<em>Icacinaceae </em>with MAO-A ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 551-555
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.