The field experiment was carried out at Annamalai Univeristy Experimental Farm, Annamalainagar to study the efficacy of application of new herbicides on weed control efficiency and nutrient intake in paddy. The experiment was laid out in a RBD with eleven treatments and three replications. The treatments comprised of T1–Unweededcontrol, T2– Pretilachlor 0.6 kgha-1 on 3 DAT, T3–Metsulfuron methyl + Chlorimuronethyl 0.004kgha-1on 3 DAT, T4 – Bensulfuron methyl + pretilachlor 0.66 kg ha-1 on 3 DAT, T5 – Pretilachlor 0.6 kg ha-1 on 3 DAT fb 2,4-D 1 kg ha-1 on 30 DAT, T6 – Metsulfuron methyl and Chlorimuron ethyl 0.004 kg ha-1 on 3 DAT fb 2,4-D 1 kg ha-1 on 30 DAT, T7 – Bensulfuron methyl + Pretilachlor 0.6 kg ha-1 on 3 DAT fb 2,4-D 1 kg ha-1 on 30 DAT, T8 – Pretilachlor 0.6 kg ha-1 on 3 DAT fb Bispyribac sodium 0.02 kg ha-1 on 30 DAT, T9 – Metsulfuron methyl + Chlorimuron ethyl 0.004 kg ha-1 on 3 DAT fb bispyribac sodium 0.02 kg ha-1 on 30 DAT, T10 – Bensulfuron methyl + Pretilachlor 0.66 kg ha-1 on 3 DAT fb Bispyribac sodium 0.02 kg ha-1 on 30 DAT and T11 – Two HW on 15 and 30 DAT. Among the therapies, application of PE- herbicide bensulfuron methyl + pretilachlor 0.66 kg ha-1 on 3 DAT followed by PoE- herbicide bispyribac sodium 0.02 kg ha-1 on 30 DAT recorded the highest weed control efficiency and nutrient uptake in transplanted rice.