Cordia macleodii (Griff.) Hook.f. and Thomson belong to the family Boraginaceae well known for its ethanomedicinal properties. Its perennial flowering plants. Its vernacular names are Dahiman, Dahipalash, Dadhipalash, Dahipalas, Gadhapalash, Dhengan, Gonni, Kuhman, Bohad, Daiwas, and Dahichir in the Hindi language. In core tribal areas of Gadchiroli and Gondia District it was used to make many indigenous medicines due to its phytochemical properties. Chemically, it contains varied numbers of phytochemicals such as glycosides, flavonoids, saponins, phenols, and terpenoids, traditionally used to prepare more than 150 herbal medicines. Bioactive compounds have been isolated from vegetative parts such as tree bark, stem, and leaves, which are helpful to treat many ailments such as antimicrobial, hepatoprotective, antioxidant, antivenom, analgesic activity, wound-healing, antidepressant, and antihypertensive, with great significance in pharmaceutical industries for developing new herbal drugs. Based upon its high value in ethnobotany, review data was gathered for socioeconomic benefits of society and conservation steps are recommended. Nowadays, people without knowing the ethanomedicinal properties of plants are cutting down forest areas; hence it is important to disseminate knowledge of ethanomedicinal plants and to conserve them in local habitats. It is a critically endangered plant distributed mainly in dry deciduous forests of India and used by tribal communities of different states of India for making various agricultural and household implements and treating various ailments and diseases. Cordia macleodii is declining fast from natural habitats due to over-exploitation and habitat degradation; hence, the present study of review was done. Consequently, arrays of biological synthesis protocols leading to the formation of nanostructures have been reported using bacteria, fungi, and plants There are many review works accomplished on silver nanoparticles stem extract of Cordia macleodii and its antibacterial activity against pathogenic bacteria like Pseudomonas aeruginosa, Staphylococcus aureus, Citrobacter sp., E. coli, CONS (coagulase-negative Staphylococci), Acinetobacter sp., Enterobacter sp., Proteus vulgaris, and Klebsiella sp. . It can be concluded that this plant has potential medicinal value and is recommended for further scientific exploration to find novel bioactive compounds of pharmaceutical importance for novel drug development for the benefit of human society.